A back-and-forth encounter was eventually settled by Poland striker Robert Lewandowski’s close-range finish with seven minutes of normal time remaining.
Following an brisk opening, Barcelona landed a mighty one-two punch on Napoli with two goals in three minutes.
First, 20 year-old midfielder Lopez took his chance to impress on the big stage as he stroked home a side-footed finish on 15 minutes after Lewandowski dummied Raphinha’s low cross.
Former Leeds winger Raphinha was also at the centre of Barcelona’s second, leading a counter-attack and curling a shot off the post before Manchester City loanee Cancelo scored from the rebound.
Barcelona however ceded momentum, and Napoli pulled one back on the half hour when Kosovan centre-back Rrahmani ventured forward to slot past Marc-Andre ter Stegen following a cutback from the right.
Napoli pushed hard for an equaliser, and missed their best chance with 10 minutes remaining as Jesper Lindstrom sent a free header wide from seven yards.
But they eventually came up short as Barcelona sealed a win for the first time in five Champions League knockout ties when Lewandowski tapped home after being set up by slick play from Sergi Roberto.
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